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5 Much of this evidence comes from observational data, so more research is needed to fully understand the reason why

32 This is unsurprising as, like nearly all medications, these agents are effective only while in use and lose efficacy once ceased

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They have about half the rates of nausea as GLP-1s, and rates of vomiting, diarrhea, and constipation that really approach placebo

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To assess the importance of the VSMC GLP-1R for BP regulation in response to GLP-1R agonism, we treated normotensive Glp1r VSM+/+ and Glp1r VSM/ mice with semaglutide and recorded BP measurements